PKM2 Enters the Morpheein Academy

PKM2 and cancer: The function of PKM2 beyond glycolysis

Metabolic reprogramming is a hallmark of cancer cells and is used by cancer cells for growth and survival. Pyruvate kinase muscle isozyme M2 (PKM2) is a limiting glycolytic enzyme that catalyzes the final step in glycolysis, which is key in tumor metabolism and growth. The present review discusses the expression and regulation of PKM2, and reports the dominant role that PKM2 plays in glycolysis...

Obstacles Facing the Iranian Basketball Academy

This study, which is a strategic study with a mixed research approach aimed to identify obstacles facing the academies of Iranian Basketball Federation. The population comprises board of directors and committees responsible for Education and Talent Spotting Association, academy administrators, physical education instructors, qualified experts, professors, coaches, referees and heads of delegati...

SUMO enters the ring

By the mid-1990s, it was clear that conjugation to ubiquitin could affect not just a protein’s stability, but also its localization and activity. Whether there were other proteins in the cell that could also be covalently linked to substrates in order to regulate their function was unknown, at least until Matunis et al. (1), along with several other groups (2–6), identified the protein that wou...

The GPU Enters Computing's Mainstream

Europe Enters the Eighties